The Brumbies have made two changes to the team that lost to the Crusaders before their bye with Scott Sio returning to the starting line up.
Sio has been named at loose-head prop and Scott Fardy returns from injury at lock.
Fardy hasn't been seen in Brumbies colours since the South African block almost a month ago where he suffered and ankle injury, but has since recovered making his way through Canberra's John I Dent Cup with Wests.
With Dan Palmer dropping from the Brumbies 22-man squad, Ruan Smith has been included on the bench for his first appearance in a Brumbies jersey.
Having previously claimed two caps for the Western Force, Smith has worked hard to maintain his Super Rugby quality during 2013 and will be looking to make a big impact at ANZ Stadium on Saturday.
A former Australian and South African Schoolboys star, Smith fits the mould of a young Ben Alexander and links nicely with fellow youngsters Sio and Siliva Siliva in the front row.
As well as Palmer, Leon Power drops out of the Brumbies 22-man squad. Peter Kimlin moves from lock to blind-side flanker, Ben Mowen to No. 8 and Fotu Auelua shifts back to the bench.
"Waratah week is one of the most important for all Brumbies players and supporters on the rugby calendar. They've been playing convincing rugby over the last month or so and the trip to Sydney presents us with a significant challenge," White said.
"It's great to see both Scotts in the starting side, Sio is now a proven starter and Fardy has been one of our most consistent players over the last two years.
"Saturday will also be an exciting time for Ruan. He's been biding his time, waiting for an opportunity and I'm sure he'll take it with both hands come Saturday night.
"There are no easy away games in this competition, we are aware of that. So to win in Sydney against an in-form Waratahs side is a big challenge.
"We have trained well this week and will be putting our best foot forward to come away from Sydney with a win."
The brumbies will hold their Captain's Run in Canberra on Friday morning before taking the bus to Sydney after lunch.
1. Scott Sio,2. Stephen Moore,3. Ben Alexander,4. Scott Fardy,5. Sam Carter,6. Peter Kimlin,7. George Smith,8. Ben Mowen,9. Nic White,10. Matt Toomua,11. Joe Tomane,12. Christian Lealiifano,13. Tevita Kuridrani,14. Henry Speight,15. Jesse Mogg
Replacements,16. Siliva Siliva,17. Ruan Smith,18. Fotu Auelua,19. Colby Faingaa,20. Ian Prior,21. Robbie Coleman,22. Pat McCabe