The Reds have named their team to play the Rebels at Suncorp Stadium on Stadium with five changes to the team that lost to the Stormers.
Hooker James Hanson will celebrate his milestone 50th game for the Queensland Reds and is one of five changes made to the starting line-up for their final Super Rugby regular season fixture before the June Test window with the Reds enjoying their second scheduled bye next week.
Director of Coaching Ewen McKenzie has re-shaped his backrow for Saturday's clash with Eddie Quirk and Beau Robinson coming in at blindside and openside flanker respectively.
Injuries to Chris Feauai-Sautia (hamstring) and Jono Lance (neck) will see Ben Tapuai come in at outside centre and playmaker Ben Lucas wear the number 15 jersey for the first time this year.
Following 13 consecutive starts to commence the season, Quirk was used as a late-game closer on the bench against the Stormers at the weekend but has been promoted once again alongside Robinson, who has successfully recovered from an early season ankle injury to have featured in the Reds past four matches.
"We're blessed here in Queensland with the amount of quality backrowers we have available to us and this depth really allows us the opportunity to use various combinations and implement different strategies relevant to our opposition," McKenzie said.
"Our players are also aware of the roles expected from them as either ‘starters' or ‘finishers' and ultimately the contributions of each, irrespective of when they are on the field, are equally as important as each other.
"Liam has been an absolute standout for us this season and combined with Radike on the bench we feel they'll make a huge difference as impact players this week while also giving two form players in Eddie and Beau a chance."
1. Greg Holmes,2. James Hanson,3. James Slipper,4. Rob Simmons,5. James Horwill (c),6. Eddie Quirk,7. Beau Robinson,8. Jake Schatz,9. Will Genia,10. Quade Cooper,11. Luke Morahan,12. Anthony Faingaa,13. Ben Tapuai,14. Rod Davies,15. Ben Lucas
Replacements : 16. Saia Faingaa,17. Ben Daley,18. Ed O'Donoghue,19. Radike Samo,20. Liam Gill,21. Nick Frisby,22. Mike Harris