Australia's Wallabies recovered from last week's loss to England by thumping Italy 15-50 at Stadio Olympico in Turin on Saturday.
The Wallabies' 20-13 defeat to England at Twickenham shot down their Grand Slam bid in their tour opener, but they got back to winning ways.
Australia made a poor start as they conceded the first try and were trailing 10-0 after 13 minutes.
However Australia finally woke up and they kicked scored 33 points without reply, with tries from Ben Mowen, Tevita Kuridrani, Nick Cummins (two), Adam Ashley-Cooper, Joe Tomane and Israel Folau.
Quade Cooper converted four, and Christian Leali'ifano two.
Luke McLean, Lorenzo Cittadini and debutant Tommaso Allan crossed for Italy's tries.
The victory is coach Ewen McKenzie's third victory since taking charge and his first over a team outside of the Rugby Championship as the other two wins were against Argentina.
Italy believed they had one of their best chances to claim a first victory over Australia after 15 defeats.
The last encounter between the sides was a narrow loss by three points a year ago, and the Wallabies were considered vulnerable with a record of eight defeats in 11 matches this year.
Italy piled on the pressure from the outset. Flyhalf Alberto di Bernardo kicked an easy penalty then Italy launched a swift attack from inside its own 22.
Tommaso Benevenuti raced down the right flank, threw inside to Luca Morisi, who passed for Australia-born Mclean to score the game's opening try. Di Bernardo's conversion made it 10-0.
That sparked a reaction from Australia, who took only three minutes to reply. Italy were withstanding heavy pressure until flyhalf Cooper passed out wide and No. 8 Mowen found a gap to score.
Four minutes later, winger Nick Cummins was hauled down just before the line but offloaded for center Kuridrani to touch down.
The Wallabies had a nine-point lead when Cummins latched onto a pass from scrumhalf Will Genia and managed to slip through a tackle from McLean before scoring in the right corner.
Italy should have reduced the deficit before halftime but di Bernardo sent two penalty kicks wide.
At the start of the second half, Cooper's pass to Cummins appeared to be forward but the video referee awarded a try and Cooper again converted as the Wallabies extended their lead to 16 points.
Italy had little to offer against heavy Australian pressure and found itself further behind on the hour when Cooper offloaded a perfectly timed pass for Ashley-Cooper to score by the right post.
Replacement prop Cittadini went over for Italy after first McLean and then Robert Barbieri were halted close to the line, however a Leali'ifano penalty was quickly followed by Tomane sprinting into the right corner.
Leali'ifano converted from the touchline and Australia had a 35-point lead and then with the outcome long beyond doubt, Australia took their foot off the pedal.
Italy attacked almost continuously until the final whistle but made little headway until Allan slipped through a gap and the 20-year-old replacement flyhalf scored a try on his debut.
Final score Italy 20 (10) Australia 50 (19)
Tries - McLean, Cittadini, Allan
Pen - Di Bernardo
Con - Di Bernardo
Tries - Mowen, Kuridrani, Cummins 2, Ashley-Cooper, J.Tomane, I.Folau
Con - Cooper 2 Leali'ifano 2
Referee: Glen Jackson (New Zealand)
Assistant referees: Romain Poite (France), John Lacey (Ireland)
Television match official: Graham Hughes (England)
Assessor: Donal Courtney (European Rugby Cup)
Luke McLean; Tommaso Benevenuti, Luca Morisi, Alberto Sgarbi, Leonardo Sarto, Alberto Di Bernardo, Edoardo Gori, Sergio Parisse (capt), Robert Barbieri, Alessandro Zanni, Marco Bortolami, Antonio Pavanello, Martin Castrogiovanni, Davide Giazzon, Michele Rizzo
Replacements :Leonardo Ghiraldini, Matias Aguero, Lorenzo Cittadini, Quintin Geldenhuys Joshua Furno, Tobias Botes, Tommaso Allan Tommaso Iannone
Israel Folau; Adam Ashley-Cooper, Tevita Kuridrani, Matt Toomua, Nick Cummins; Quade Cooper, Will Genia; James Slipper, Stephen Moore, Ben Alexander; Sitaleki Timani, James Horwill; Rob Simmons, Michael Hooper, Ben Mowen (captain)
Replacements: Saia Fainga'a, Benn Robinson, Sekope Kepu, Dave Dennis, Liam Gill, Nic White, Christian Leali'ifano, Joe Tomane