England have announced that Leicester Tigers hooker Tom Youngs will mis the tour of New Zealand in order to stay at home to support his wife who is requiring treatment for an illness.
Leicester Tigers Director of Rugby Richard Cockerill said: "These things are more important than rugby, and Tom and his family have the full support of everyone at Leicester Tigers. We hope everyone respects their privacy at this time."
England Head Coach Stuart Lancaster said: "Our thoughts are with Tom and Tiffany at this time and it is entirely right that he stays at home to support her and their daughter Maisie. Everyone in the England squad sends them our best wishes."
In addition, Alex Corbisiero (Northampton Saints), Tom Croft (Leicester Tigers), Jack Nowell (Exeter Chiefs) and Christian Wade (London Wasps) will not tour.
Lancaster added: "Alex and Tom have worked really hard to come back before the end of the season but they will not have played enough rugby for them to be considered for such a tour. It's the same with Christian Wade. "
"They have all had significant injuries and their return to play has been carefully managed in conjunction with their clubs. It will be a short term loss but a long term gain for us and their clubs as we enter a huge 18 months.
"Jack needs to get his knee sorted so he will be ready for next season and the World Cup and it's the right decision for him to have the operation next week."
England's medical team are liaising with Bath Rugby and Gloucester Rugby over injuries to Rob Webber (knee) and Billy Twelvetrees (ankle) respectively.