Juan de Jongh and Marnitz Boshoff have been ruled out of South Africa's Test match against Wales in Durban because of illness and injury.
De Jongh was admitted to a Durban hospital on Sunday evening with a severe chest infection.
He will in all likelihood only be discharged by Wednesday and will not be ready to take on Wales this weekend.
Boshoff rolled his right ankle at training in Cape Town last week. He has a grade one ankle sprain and the Springbok medical team are hopeful that he would be able to start training again late this week.
A decision on both players' further involvement in the Series against Wales will only be taken at a later stage and they will remain with the squad for the time being.