Wales have named three debutants in their team to face the Barbarians and have also named veteran flanker Martyn Williams on the bench wherehe is set to win his 100th cap at Millennium Stadium.
If the retiring 36-year-old flanker enters the fray in Cardiff, he will become the third Welsh player - after Stephen Jones and Gareth Thomas -to reach the milestone.
The Six Nations winners are using the game as a warmup for the three-test tour of Australia next week, and caretaker coach Rob Howley has named a team containing three uncapped players - fullback Liam Williams, prop Rhodri Jones and winger Harry Robinson.
"We have picked a side on form, with an eye on bringing players through for the future, but very much with the intention of getting the summer campaign off to a winning start," said Howley, who was in charge while head coach Warren Gatland recovers from surgery to his heels.
The final 34-man squad for the Australia tour, which also includes a midweek game against the Brumbies, will be confirmed after Saturday's match.
Liam Williams, Harry Robinson, Adam Bishop, James Hook, Aled Brew, Dan Biggar, Lloyd Williams; Ryan Jones, Justin Tipuric, Josh Turnbull, Ian Evans, Alun-Wyn Jones, Rhodri Jones, Matthew Rees (captain), Rhys Gill.
Reserves: Richard Hibbard, Paul James, Aaron Shingler, Martyn Williams, Rhys Webb, Adam Warren, Will Harries