Reds vice captain Will Genia will captain Australia after regular captain James Horwill was ruled out of this weekend's match against South Africa through injury.
Horwill is expected to miss just one week of Rugby Championship action in Brisbane after a scan revealed he had strained his left hamstring during Tuesday's training.
Reds captain Horwill will be replaced by Kane Douglas who will line up alongside fellow lock Rob Simmons, while Western Force backrower Ben McCalman was named as a new forward replacement on the bench.
Genia has skippered the Wallabies on three previous occasions, most recently leading the team to a 26-19 victory over South Africa in Perth last September.
"Will is a proven leader and has had plenty of success as captain for the Queensland Reds and also for Australia," Wallabies coach Ewen McKenzie said.
"He is a player that thrives with the added responsibility and he has always stepped up when given the opportunity to lead. I'm sure this will bring the best out of him.
"It's extremely disappointing to lose James but after discussions with medical staff we felt it was important not to risk further injury when he isn't ready."
McKenzie said he expected Horwill to be available for the two-game tour of South Africa (September 28) and Argentina (October 5).
"It's extremely disappointing to lose James but after discussions with medical staff we felt it was important not to risk further injury when he isn't ready," Wallabies coach Ewen McKenzie said.
"Scans revealed his injury was on the lower-end in terms of severity and we expect him to be back to full fitness when we embark on our two-game tour of South Africa and Argentina in a few weeks."
Israel Folau; Nick Cummins, Adam Ashley-Cooper, Christian Lealiifano, James O'Connor; Quade Cooper, Will Genia (capt); Ben Mowen, Michael Hooper, Scott Fardy; Kane Douglas, Rob Simmons; Sekope Kepu, Stephen Moore, James Slipper.
Replacements: Saia Faingaa, Scott Sio, Ben Alexander, Ben McCalman, Jake Schatz, Nic White, Matt Toomua, Jesse Mogg.