Wallaby and Waratahs winger Drew Mitchell's hopes of playing the Rugby World Cup are over after a serious ankle injury in Brisbane.

The Waratahs have confirmed that Mitchell will miss the remainder of the Super Rugby season.

Mitchell was driven from the field in the medical buggy after he tripped playing against the Reds in Brisbane with a serious ankle injury.

Mitchell was chasing a ball when he ran into the back of Scott Higginbotham and fell awkwardly.

The match was immediately stopped by referee Steve Walsh and Mitchell was clearly in pain.

Early medical reports are that he dislocated his right ankle and has a broken bone in his leg.

Mitchell had to be had to be sedated as his ankle was put back into place by medical staff on the field.

"He'll be gone for the year," said Waratahs coach Chris Hickey to Fox Sports

"It's a pretty significant injury."

"I think it rattled anyone who saw it," Waugh said.

"It was disappointing - you don't want to see that happen to anyone in the world in any sport."

The Rugby world cup runs from September the 9th to October the 23rd and Mitchell was almost certain to make the Australian World cup squad.