The Cheetahs have made one change to the team that beat the Force last weekend for this week's clash at newlands against the Stormers.
Veteran Tewis de Bruyn was the coach's choice for the Cheetahs' last couple of games against the Highlanders and Western Force, but De Bruyn struggled to provide magic on attack.
Drotske hoped Van Zyl's return would spark something special against a Stormers side that are the clear favourites for the game at Newlands.
"Piet is a very good attacking player," Drotske said.
"He made a big impact from the bench against the Highlanders and Force and hopefully he can do the same starting against the Stormers."
Van Zyl's inclusion is the only change to the Cheetahs side that struggled to a 17-13 victory at home last week against the Western Force.
Drotske has again backed flyhalf Sias Ebersohn, even though he missed four kicks at goal against the Perth-based side.
"Sias did well, especially with all the pressure on him after missing that vital kick against the Highlanders [the week before].
"He will be back and we are confident he will have a good game against the Stormers."
Springbok centre Andries Strauss was cleared to play early Wednesday morning after picking up a rib injury against the Force.
Lock Andries Ferreira is also available after he was cleared late Tuesday afternoon of foul play.
Ferreira was cited for a dangerous tackle on Force eighthman Matt Hodgson but was later cleared of all charges.
The match will be a special occassion for Heinrich Brüssow as he will be playing in his 50th Super Rugby match for the Cheetahs.
1 Coenie Oosthuizen,2 Adriaan Strauss (C),3 WP Nel,4 George Earle,5 Izak van der Westhuizen,6 Heinrich Brüssow,7 Justin Downey,8 Philip van der Walt,9 Piet van Zyl,10 Sias Ebersohn,11 Willie le Roux,12 Andries Strauss (VC),13 Robert Ebersohn,14 Cameron Jacobs,15 Hennie Daniller
Replacements : 16. Hercu Liebenberg,17. Trevor Nyakane,18. Andries Ferreira,19. Ashley Johnson,20. Tewis de Bruyn,21. Riaan Smit,22. Philip Snyman