The Sharks missed out on playing the Rebels in 2012 so the only time the teams have met in Super Rugby was the Rebels fourth round match during 2011 in Melbourne.
The match in Melbourne was won 32-34 by the Sharks so the Rebels have never played in Durban before.
2012 Super Rugby finalists the Sharks have made several changes to their team for Saturday's clash in Durban after they lost 10-29 to the Brumbies.
Springbok centre Frans Steyn, prop Jannie du Plessis and Ryan Kankowski were all dropped to the bench, while Pieter Steph du Toit (lock) and Kyle Cooper (hooker) have forced their way into the starting line-up.
Wiehahn Herbst (prop) and Jacques Botes (flank) comes into the team and skipper Keegan Daniel moves from the side of the scrum back to No 8.
Further changes to the team that was on the losing side last week against Jake White's team see Lwazi Mvovo back in the No 11 jersey for Odwa Ndungane and Cobus Reinach at scrumhalf for Charl McLeod.
Meanwhile the Rebels have been able to recall captain Gareth Delve who returns from injury for their first tour match in Durban.
The Rebels also welcome back Wallaby winger, Cooper Vuna, who has missed the team's opening matches with a scapular injury he sustained in the first trial last month.
Rebels Head Coach, Damien Hill, has also rewarded promising New Zealand born winger Jason Woodward selecting the talented rookie in the run on side for his debut.
Prop Laurie Weeks will earn his 50th Super Rugby cap. Kurtley Beale and Kimami Sitauti was not considered because of injury.
The Rebels had a bye last week so they can be expected to start a little slowly as it can take 20 minutes to get back up to match speed.
The Sharks have come in for plenty of criticism this season as they are last in the team list for scoring tries with only three in four matches.
The loss to the Brumbies didn't help slow the criticism and if they lose this week many will write them off as contenders for the title. By the same token a big victory could get the back on the right track. They have everything in their favour this week.
The Bookies have given the Rebels a 14 point start for this Match - with an offer of a FREE $150 BET. We think the Sharks should win this match comfortably. Sharks to win by 9.
This Match will be shown on TV in NZ, Aus, SA and in the UK on Sky Sports 1 on the Red button as well as the website.
Average score: Sharks 34 Rebels 32
11 Mar 2011 Sharks v Rebels 34-32 Melbourne
Sharks overall record against the Rebels
Played 1, Wins 1, Losses 0, Draws 0
Match No.33. :Sharks v Rebels
Date : Saturday 23 March
Venue : Kings Park, Durban
Kick Off local: 17:05
Referee: Lourens van der Merwe
Assistant Ref 1:Stuart Berry
Assistant Ref 2:Reuben Rossouw
TMO : Shaun Veldsman
1. Tendai Mtawarira , 2. Kyle Cooper , 3. Wiehahn Herbst , 4. Pieter-Steph du Toit , 5. Franco van der Merwe , 6. Jacques Botes , 7. Marcell Coetzee , 8. Keegan Daniel (Captain) , 9. Cobus Reinach , 10. Patrick Lambie , 11. Lwazi Mvovo , 12. Meyer Bosman , 13. Paul Jordaan , 14. JP Pietersen , 15. Louis Ludik
Replacements , 16. Craig Burden , 17. Jannie du Plessis , 18. Jandre Marais , 19. Ryan Kankowski , 20. Charl McLeod , 21. Francois Steyn , 22. Riaan Viljoen
1. Nic Henderson,2. Ged Robinson,3. Laurie Weeks,4. Hugh Pyle,5. Luke Jones,6. Scott Higginbotham,7. Scott Fuglistaller,8. Gareth Delve (c),9. Nick Phipps,10. James O'Connor,11. Cooper Vuna,12. Lachlan Mitchell,13. Mitch Inman,14. Jason Woodward,15. Angus Roberts
16. Shota Horie,17. Paul Alo-Emile,18. Cadeyrn Neville,19. Jordy Reid,20. Nic Stirzaker,21. Rory Sidey,22. Richard Kingi.