The Reds will be aiming to beat the Blues this weekend on Friday in order to achieve their first clean sweep of New Zealand teams in one season.
The Reds miss out on playing the Crusaders in 2013 due to the draw but have already beaten the Hurricanes, Highlanders and Chiefs.
The Queenslanders have not beaten all of the New Zealand teams in their fixture list in one year since rugby went professional in 1996.
"They've got some outstanding footwork and are very quick so we are going to have to be on our game. Once again we are going to have to change our game plan.
"It's our last Kiwi team of the competition. We've got to make sure we go out there and get the job done.
"It is going to be a physical and fast game because the Blues do run the ball a lot and they play with a lot of width and attacking across the park."
"The Blues have probably got some of the most exciting back three players in the competition," Horwill warned of what to expect at Suncorp Stadium on Friday.
Meanwhile director of coaching Ewen McKenzie has dismissed speculations that Digby Ioane will be leaving the franchise as according to McKenzie he still has a year left on his contract.
Horwill has also rejected talk of him leaving the Reds after reports in a newspaper surfaced which said that he was in dispute with the Reds over new contract negotiations.
"That's completely untrue from my end," Horwill told the The Courier-Mail.
"As I've said before, I'd find it very difficult to play for another Australian team other than the Reds."
The Reds will go into the match against the Blues on the back of a frustrating draw with the Brumbies in Brisbane but McKenzie says that they just needed to fix a few things.
"We'll all go away and try to fix our bits. There is always stuff to fix and we've found plenty already, so we will just concentrate on that," McKenzie said.
McKenzie said that the Reds missed opportunities in the draw with the Brumbies was their greatest shortcoming because even though they scored three tries they far more chances.
"We've tracked well against the Kiwi sides. We need to come with a different approach to the game."
"We need to deal with their strengths and also put pressure on them, and I feel we are well positioned to do that.
"We are going to have to have our wits about us. They have good strikepower and it is structured with some method about how they do it. It's not just random play and they have some really good individuals," McKenzie said.