The Blues secured back to back victories when they beat the Reds 44-14 with a bonus point at Eden Park in Auckland on Friday.
The result extends the Blues unbeaten run at home against all teams in 2014 to five matches from five.
The victory for the Blues moved them into the play off places and ended a four match losing streak to the Queensland side.
The loss for the Reds is their seventh this season from ten matches and they remain in 13th place above the Cheetahs and Stormers.
The Blues have also played ten matches this season and have won five.
All Blacks centre Ma'a Nonu played a key role in three tries for the Blues who needed needed only 50 minutes to capture a four-try bonus point, posting their second straight win over an Australian opponent.
Nonu laid on the opening try for midfield partner Jackson Willison, then created tries for Lolagi Visinia and Bryn Hall in a five-minute spell on either side of halftime when the Reds were down to 14 men.
Blues flyhalf Simon Hickey converted four tries and landed three penalties - seven goals from seven attempts - to surpass 100 points for the season.
After conceding four tries to trail 34-0 by the 50th minute, the Reds rallied with tries to Ben Daley and captain James Horwill to take some of the weight from a lopsided scoreline.
But the Blues finished strongly with a try to replacement Ihaia West to secure their fifth win at home this season.
They started the match in last place in the New Zealand conference - though only five points behind regional leaders the Hurricanes - just as Queensland were in last place in Australia.
Wallabies flyhalf Quade Cooper, who was celebrating his 100th match in a Queensland jersey, missed two penalties to cost his team the chance to get into the match early on and finished with two goals from four attempts.
The Reds were also unlucky to have tries to back-rowers Liam Gill and Jack Schatz disallowed in either half.
The match began on a low note in a first quarter heavily punctuated by penalties - and the Blues needed 32 minutes to open the scoring through Willison, who was immediately forced from the field with a hamstring strain.
Nonu opened up the Queensland defence with a wide pass to winger Visinia, who turned the ball back to Willison for the try.
Wallabies prop James Slipper was sent to the sin-bin in the 35th and in his absence Nonu fashioned tries for Visinia and Hall.
His chip kick into unoccupied territory behind the posts made Visinia's try in the 38th. Nonu then made the break that led to a try by scrumhalf Hall in the 43rd, lifting the Blues to 27-0.
Nonu also handled in the next try-scoring movement but it was Frank Halai's break and pass that made the try by lock Tom Donnelly which secured the Blues' four-try bonus point.
All Blacks prop Tony Woodcock was sent to the sin-bin for punching the 52nd and, in his absence, Queensland scored its first try through Ben Daley. The Reds closed the gap a little with Horwill's try in the 65th but the Blues finished strongly.
Final Score Blues 44 (20) Reds 14 (0)
Tries - J.Willison, L.Visinia, B.Hall, T.Donnelly, I.West
Pen - S.Hickey 3
Con - S.Hickey 4, I West
Cards - T.Woodcock
Tries - B.Daley, J.Horwill
Con - Q.Cooper 2
Cards - J.Slipper (34th min yellow)
Referee: Nick Briant
Assistant Ref 1: Mike Fraser
Assistant Ref 2: Brendon Pickerill
TMO: Glenn Newman
15. Charles Piutau,14. Frank Halai,13. Jackson Willison,12. Ma'a Nonu,11. Lolagi Visinia,10. Simon Hickey,9. Bryn Hall,8. Jerome Kaino,7. Brendon O'Connor,6. Peter Saili,5. Tom Donnelly,4. Patrick Tuipulotu,3. Charlie Faumuina,2. Keven Mealamu (C),1. Tony Woodcock,
Replacements : 16. James Parsons,17. Ofa Tu'ungafasi,18. Angus Ta'avao,19. Hayden Triggs,20. Steven Luatua,21. Piri Weepu,22. Ihaia West,23. George Moala
1. James Slipper,2. Saia Fainga'a,3. Greg Holmes,4. Rob Simmons,5. James Horwill (C),6. Eddie Quirk,7. Liam Gill,8. Jake Schatz,9. Will Genia (VC),10. Quade Cooper,11. Rod Davies,12. Anthony Fainga'a,13. Ben Tapuai,14. Chris Feauai-Sautia,15. Mike Harris
Replacements : 16. James Hanson,17. Ben Daley,18. Jono Owen,19. Ed O'Donoghue,20. Beau Robinson,21. Nick Frisby,22. Ben Lucas,23. Jamie-Jerry Taulagi